Publications

2026

  • Richman DE, Wendorff TJ, Rashid F, Beck C, Yan Q, Johnson HR, Eckerty RA, Fogg JM, Baker ML, Zechiedrich L, Berger JM. “Supercoiled DNA recognition and cleavage control in topoisomerase VI.” Nature Communications, 2026.
  • Zheng I, Learn B, Bailey S. “Structural basis for inhibition of SpyCas9 by the anti-CRISPR protein AcrIIA26.” Biochemical Journal, 2026;483(3):289.
  • Liang X, Pathak R, Qiu X, Dillard L, Twomey EC, Müller U. “Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15 critical for mechanotransduction.” PNAS, 2026 (posted to bioRxiv March 2, 2026 as 2026.03.02.709101).
  • Wang H, Weaver MG, Carrillo E, Zheng I, Gu W, Khau J, Mondal AK, Yanez A, O’Brien E, Jayaraman V, Twomey EC. “GluDs are ionotropic dopamine receptors tuned by G-proteins.” Posted to bioRxiv May 10, 2026 (2026.05.10.723887).
  • Mondal AK, Wang H, Weaver MG, Zheng I, Kormshchikov N, Ahmed F, Twomey EC. “Molecular basis for ligand-gating of the human GluD1 receptor.” Posted to bioRxiv April 6, 2026 (2026.04.06.716743).
  • Park G, Wu C, Louder RK. “Structural mechanism of histone H2A.Z exchange by human SRCAP-CFDP1 holoenzyme.” Science Advances, 2026.

2025

  • Dar MA, Louder R, Cortes M, Chen R, Ma Q, Chakrabarti M, Umanah GKE, Dawson TM, Dawson VL. “Cryo-EM structure of AAA+ ATPase thorase reveals novel helical filament formation.” Computational and Structural Biotechnology Journal, 2025.
  • Zheng W, Hagino T, Wang H, Cheng HY, Koylass N, Chen KH, Wang H, Mani S, Mondal AK, Twomey EC, Qiu Z. “Puromycin-sensitive aminopeptidase acts as an inhibitory auxiliary subunit of volume-regulated anion channels.” Molecular Cell, 2025;85(24):4621–4632.e7.
  • Li Y, Cao X, Recker LM, Yang Y, Liu C. “Structural and catalytic diversity of coronavirus proofreading exoribonuclease.” Nature Communications, 2025;17:452.
  • Hale WD, Wang H, Huganir RL, Twomey EC. “Structural basis for activation and conformational plasticity of the GluA4 AMPA receptor.” Posted to bioRxiv June 12, 2025 as “Architecture, Activation, and Conformational Plasticity in the GluA4 AMPA Receptor” (2025.06.12.659357); published in Nature Communications, 2026.
  • Montaño Romero A, Yovanno RA, Lau AY, Twomey EC. “Mechanisms of Ion Permeation in the AMPA Receptor Ion Channel.” Posted to bioRxiv June 27, 2025 (2025.06.27.662003).
  • Rahman S, Hicks CW, Gwizdala A, Wolberger C. “Mechanism of USP21 autoinhibition and histone H2AK119 deubiquitination.” Science Advances, 2025;11(41):eady2604.
  • Hicks CW, Gliech CR, Zhang X, Rahman S, Vasquez S, Holland AJ, Wolberger C. “Haspin kinase binds to a nucleosomal DNA supergroove.” Nature Structural & Molecular Biology, 2025.
  • Kumar Mondal A, Carrillo E, Jayaraman V, Twomey EC. Glutamate gating of AMPA-subtype iGluRs at physiological temperatures. Nature. 2025 Mar 26;. doi: 10.1038/s41586-025-08770-0. [Epub ahead of print] PubMed PMID: 40140570.
  • Hale WD, Romero AM, Koylass N, Warrick CR, Qiu Z, Huganir RL, Twomey EC. Structure of transmembrane AMPA receptor regulatory protein subunit γ2. Nat Commun. 2025 Jan 15;16(1):671. doi: 10.1038/s41467-025-56027-1. PubMed PMID: 39809794; PubMed Central PMCID: PMC11733119.

2024

  • Louder RK, Park G, Ye Z, Cha JS, Gardner AM, Lei Q, Ranjan A, Hollmuller E, Stengel F, Pugh BF, Wu C. “Molecular basis of global promoter sensing and nucleosome capture by the SWR1 chromatin remodeler.” Cell, 2024;187(24):6849–6864.e18.
  • Park G, Patel AB, Wu C, Louder RK. “Structures of H2A.Z-associated human chromatin remodelers SRCAP and TIP60 reveal divergent mechanisms of chromatin engagement.” Posted to bioRxiv July 30, 2024 (2024.07.30.605802).
  • Wu S, Gabelli SB, Sohn J. “The structural basis for 2′-5′/3′-5′-cGAMP synthesis by cGAS.” Nature Communications, 2024;15:4012.
  • Wu S, Garg A, Mazanek Z, Belotte G, Zhou JJ, Stallings CM, Lueck J, Roland A, Chattergoon MA, Sohn J. “Design principles for inflammasome inhibition by pyrin-only-proteins.” eLife, 2024.
  • Usmani M, Coudray N, Riggi M, Raghu R, Ramchandani H, Bobe D, Kopylov M, Zhong ED, Iwasa JH, Ekiert DC, Bhabha G. “Cryo-ET reveals the in situ architecture of the polar tube invasion apparatus from microsporidian parasites.” PNAS, 2024.
  • Hale WD, Montaño Romero A, Gonzalez CU, Jayaraman V, Lau AY, Huganir RL, Twomey EC. Allosteric competition and inhibition in AMPA receptors. Nat Struct Mol Biol. 2024 Nov;31(11):1669-1679. doi: 10.1038/s41594-024-01328-0. Epub 2024 Jun 4. PubMed PMID: 38834914; PubMed Central PMCID: PMC11563869.
  • Mondal AK, Carrillo E, Jayaraman V, Twomey EC. Temperature Sensitive Glutamate Gating of AMPA-subtype iGluRs. bioRxiv. 2024 Sep 7;. doi: 10.1101/2024.09.05.611422. PubMed PMID: 39282358; PubMed Central PMCID: PMC11398517.
  • Carrillo E, Montaño Romero A, Gonzalez CU, Turcu AL, Chen SR, Chen H, Pan HL, Vázquez S, Twomey EC, Jayaraman V. Memantine Inhibits Calcium-Permeable AMPA Receptors. bioRxiv. 2024 Jul 4;. doi: 10.1101/2024.07.02.601784. PubMed PMID: 39005433; PubMed Central PMCID: PMC11245036.
  • Montaño Romero A, Bonin C, Twomey EC. C-SPAM: an open-source time-resolved specimen vitrification device with light-activated molecules.IUCrJ. 2024 Jan 1;11(Pt 1):16-22. doi: 10.1107/S2052252523010308. PubMed PMID: 38096039; PubMed Central PMCID: PMC10833387.

2023

  • Hale WD, Montaño Romero A, Koylass N, Warrick CR, Qiu Z, Huganir RL, Twomey EC. “Structure of transmembrane AMPA receptor regulatory protein subunit γ2.” Posted to bioRxiv November 28, 2023 (2023.11.28.569079); published in Nature Communications, 2025;16:671.
  • Garg A, Stallings CM, Sohn J. “Filament assembly underpins the dsDNA specificity of AIM2-Like Receptors.” Nucleic Acids Research, 2023;51(6):2574–2584.