Beckman Center for CryoEM at Johns Hopkins
The Beckman Center for Cryo-EM at Johns Hopkins provides cutting edge cryo-EM to the Johns Hopkins and regional communities. Located in the Rangos building on the Johns Hopkins University School of Medicine campus, the center houses a 300 kV G3 Titan Krios TEM, along with a 200 kV Glacios TEM and an Aquilos II for FIB-SEM and cryo-CLEM. The Beckman Center is equipped for all aspects of high-resolution single-particle cryo-EM and tomography data collection, as well as preparation of samples for both single-particle cryo-EM and tomography.
Status
Titan Krios: Up
Glacios: Up
Aquilos: Up
Vitrobot 1 (PCTB): Up
Vitrobot 2 (Rangos): Up
Recent Publications
Richman DE, Wendorff TJ, Rashid F, Beck C, Yan Q, Johnson HR, Eckerty RA, Fogg JM, Baker ML, Zechiedrich L, Berger JM. “Supercoiled DNA recognition and cleavage control in topoisomerase VI.” Nature Communications, 2026.
Zheng I, Learn B, Bailey S. “Structural basis for inhibition of SpyCas9 by the anti-CRISPR protein AcrIIA26.” Biochemical Journal, 2026;483(3):289.
Liang X, Pathak R, Qiu X, Dillard L, Twomey EC, Müller U. “Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15 critical for mechanotransduction.” PNAS, 2026 (posted to bioRxiv March 2, 2026 as 2026.03.02.709101).
Wang H, Weaver MG, Carrillo E, Zheng I, Gu W, Khau J, Mondal AK, Yanez A, O’Brien E, Jayaraman V, Twomey EC. “GluDs are ionotropic dopamine receptors tuned by G-proteins.” Posted to bioRxiv May 10, 2026 (2026.05.10.723887).
Mondal AK, Wang H, Weaver MG, Zheng I, Kormshchikov N, Ahmed F, Twomey EC. “Molecular basis for ligand-gating of the human GluD1 receptor.” Posted to bioRxiv April 6, 2026 (2026.04.06.716743).